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-synuclein, which happens to be a primary element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which can be an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) stress, suggest that dysfunction of the intracellular proteinase systems, which include ubiquitin-proteasome procedure or lysosomal procedure, which gets rid of
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